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Knocking Out ALL  


By Drs. David Niesel and Norbert Herzog

Every now and then things go right, really, really right. In an immunotherapy clinical trial, 27 of the 29 leukemia patients went into sustained remissions, which is a whopping 93 percent success rate!

Acute lymphocytic leukemia, or ALL, is a cancer that arises in the bone marrow, the soft center of flat bones. In the bone marrow, blood stem cells give rise to all blood cells. ALL arises from the cells that become lymphocytes, a type of white blood cell. Acute in the name means that it can progress quickly and if not treated can be fatal within a few months. If the ALL cancer cells occupy more than 25% of the bone marrow, the disease is called leukemia.

Lymphocytes are a major part of the immune system found in lymphoid tissues as well as circulating in the blood. Lymphocytes come from immature cells called lymphoblasts and mature into 2 main types of cells, B cells and T cells. T cells serve a variety of functions, from orchestrating the immune response to an invader, to killing infected cells or killing microbes directly.

ALL does not form masses, but rather takes over the bone marrow and spreads to the lymph nodes, spleen and liver. The prognosis for ALL depends on age - the younger you are, the better. Prognosis also depends on the numbers of cancer cells, abnormalities the tumor DNA, and how quickly the leukemia responds to treatment. Treatment usually involves chemotherapy, targeted therapy or stem cell transplants and can last about 2 years. About 80-90 percent of adult patients have complete remissions, but about half relapse giving an overall cure rate of about 40 percent.

The study with the 93 percent response rate involved patients whose other treatments had failed and they had only a few months to live. Scientists isolated what are called killer T-cells from the patients. These cells can attack and kill cancers cells. The researchers engineered these T cells to target the patients ALL cells. They genetically engineered the T cells with synthetic molecules called chimeric antigen receptors, or CARs, that enable them to target and destroy tumor cells. Cells were expanded and then infused into the patients. More than ninety percent of the patients achieved remission of their cancers within 30-60 days however, 7 developed a severe immune response that required time in intensive care and an additional 2 patients died. Adjusting T cell dosages infused eliminated these unwanted effects. Unlike other treatments, the T cells will continue to grow and provide ongoing protection. These results from patients with such advanced stages of ALL is impressive.

This is a relatively new type of approach called immunotherapy by which our body's own immune system is programmed to attack a cancer. An advantage of this type of therapy is that it is likely to have fewer side effects and would have long lasting cancer-killing abilities should cancer cells arise later. For those patients that relapse or for whom conventional treatments fail, this approach provides new hope. So stay tuned, we will undoubtedly be hearing much more about immunotherapy in the future and the future looks pretty good already.

Medical Discovery News is a weekly radio and print broadcast highlighting medical and scientific breakthroughs hosted by professor emeritus, Norbert Herzog, and professor, David Niesel, biomedical scientists at the University of Texas Medical Branch at Galveston. Learn more at www.medicaldiscoverynews.com

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From Cannoli in South Philly to Brain Mapping in Geneva  
As a scientific conference approaches, I always think back to my first science fair: I stood next to my homemade presentation of graphs and tables glued to a poster board positioned next to hundreds of others made by fellow elementary school students. An overweight Paisan from rural New Jersey, I was more looking forward to my post-presentation reward of cannoli from my favorite bakery in South Philly than I was to standing for hours on end answering questions from the judges.

Conferences these days are pretty similar to the science fairs from decades ago, just on a grander scale with better technology. For example, every year the Organization for Human Brain Mapping (OHBM) brings together thousands of scientists who work with brain imaging data from around the world to share hot off the press findings that they just published or are preparing to publish. This year, 4,391 presentations will be on hand in Geneva for our annual conference. While there, thousands of us will stand next to posters as I did so many years ago, and a few lucky ones will be given the opportunity to present their work in front of a larger audience.

Most of these presentations are 12-15 minute bite-sized versions of a neuroimaging research project, which could easily be expanded to a 45-60 minute lecture. At the OHBM conferences, we have longer lectures too. Our Program Committee chooses outstanding speakers to summarize their own work in the context of the diverse field of brain mapping. This diversity is reflected in the wide range of topics at the conference spanning spatial scales (from single neurons to entire systems), behaviors (our senses, decision making, aging, consciousness, development, etc.), populations (healthy typical humans, populations with different clinical or psychiatric disorders, etc.) and of course, applications (computational models, artificial intelligence, etc).


Brain mappers looking at posters this afternoon during this year's Organization for Human Brain Mapping meeting in Geneva.

For me, I'm a huge fan of the fusiform gyrus - so much so that at 33, I've already spent a third of my life staring and measuring this spindle-shaped brain structure. It's probably unsurprising then that I'm looking forward to learning about new ways to measure and quantify the fusiform in the living human brain at this year's meeting. The fusiform is interesting because it's involved in human-specific aspects of cognition such as reading and functional and structural abnormalities of the fusiform have been linked to disorders like autism.

The fusiform aside, conferences aren't all about being bombarded with data. Instead, they are also about re-connecting with people from the field who you know and setting foundations for new collaborations over a coffee or a pint or even a hike. Discussions of future collaborations also happen between organizations. For example, as Geneva is the home base for the World Health Organization (WHO), both organizations took the opportunity to set up a jointly held symposium between OHBM and WHO. Representatives from the major international brain initiatives will speak to raise awareness about current research projects that impact the staggering burden of brain disorders, and what we all might be able to do to reduce these burdens in the future. After all, understanding how the brain works is a team effort - no one can do it alone.


This is a cortical surface reconstruction of a right hemisphere averaged across 39 adults. This image is from FreeSurfer, which is an open source software package that you can download here. You are looking at the underside of the brain, which is rotated so the back is in the left of the image and the front in the right of the image. The fusiform gyrus (FG) is outlined in red. Fusiform is latin for spindle-shaped. Emil Huschke labeled this structure in 1854 because it is wider in the middle and tapers off at the ends like a spindle.

We also can't expect every single researcher at the meeting to blog about their presentations. And that's where Kat, Tzipi, Brendan, Emma, and I come in. As members of the OHBM Communications Committee, our boots (or for me, flip flops) are on the ground as we listen to the poster presentations. Our butts are in the chairs as we listen to the lectures. All the while, our fingers - the same ones that write the code to analyze our own data and that write our own empirical papers - will be typing away to come back and report to you what happened at the OHBM conference and at the meetings between OHBM and WHO.

And it's not just the five of us. There's a whole team of us. For example, we have already begun to post interviews with a subset of this year's speakers on our blog with more to come. Additionally, content from this year's meeting will soon be uploaded to our main site, which already contains lectures and courses from past meetings.

We are energized by the science and the thrill of discovery, and we love sharing these discoveries with all of you. And that's the main reason why we write and blog - to provide you with foundational information and up-to-date findings about the brain at the click of a button. We hope our posts give you insight into how your brain works and how to become informed consumers of neuroimaging news.

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Out of this world cuisine  
g-ASTROMOMY merges cosmology with fine dining  
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The Freakonomics Of Gun Control  
At 11 AM on the morning of June 15, Senator Chris Murphy of Connecticut began a filibuster on the Senate floor in the wake of the Orlando mass shooting that claimed 49 lives. The objective of Senator Murphy's marathon speech was to secure Senate votes on two gun control measures: a ban on gun sales to suspected terrorists -- the so-called "No fly, no buy" measure, as well as an expansion of background checks to include gun shows and Internet sales.

By the time Senator Murphy ended his filibuster 15 hours later, an additional 12 Americans had been shot to death.

There was no national media coverage of those 12 victims, so the circumstances of their deaths are not widely known. Were they:

A: Murdered by Islamic jihadists
B: Shot by assault rifles
C: Killed in mass shootings
D: None of the above

The correct answer is "D: None of the above."

Though mass shootings like Orlando are shocking and grab headlines, the reality is that a very small percentage of American victims of gun violence die in mass shootings. Though the 49 who died in Orlando have the country's full attention, it is the actually 12 who died during Senator Murphy's 15-hour filibuster that hold the skeleton key to gun violence in America.

Depending on their political stripes, most Americans' short list of solutions to gun violence includes either: a) a ban on assault weapons, b) expanded background checks, or c) an end to the radical Islamic threat.

None of these solutions speak to directly to the causes that enabled those 12 people to die.

If a magic wand could instantly rid the U.S. of all assault rifles, Islamic terrorists and mass shootings, it would scarcely move the needle on the gauge of American gun homicides -- a trifling 7 percent of the more than 11,000 people who are shot to death every year in this country:



The majority of American gun homicide victims share the following in common:

• They are killed by handguns, not assault rifles
• They are killed by fellow Americans
• Their killers were not the gun owners of record

It is this last item that is the key to solving gun violence in America.

All guns used to kill people in the U.S. were purchased legally at some time, though few of those guns are in the possession of their original owners at the time they kill. The problem that dwarfs the issues of assault rifles and terrorists is that all firearms may be transferred in America without detection or accountability.

Though the sale of an automobile in America requires an official transfer of title, the sale of a firearm does not. Many, if not most, guns used to kill people in America are acquired through straw purchases -- purchases made on behalf of another person.

Herein lies the elegant solution to gun violence in America: simply hold the owner of record accountable for crimes committed with their guns -- that's it.

If gun owners are forced to assume responsibility for their guns, they will be far less likely to sell their guns without a formal title transfer. They will be more likely to secure their guns in a gun safe. And they may be less eager to carry their guns when they dine out at their local Pizza Hut.

Not surprisingly, the NRA is hostile to the concept of a national gun registry -- this despite the fact it in no way infringes on 2nd Amendment rights. Though the Constitution may allow you to own a gun, it doesn't say anything about prohibiting the government from knowing that you own a gun. If this seems like a scary notion to those who await the federal invasion of Texas scheduled for any day now, well, perhaps paranoia should count as one of the mental defects that disqualifies people from owning firearms.

Making gun owners accountable for their guns instantly freezes the supply of fresh arms into criminal hands. For the 300 million-plus guns already in circulation, buy back programs, such as those implemented in Australia, would siphon many of these off the streets, reducing supply and driving up the price of illegal guns.

The pushback excuses on a gun registry include: "what if my gun is stolen?" My recommendation is this: if you can demonstrate that thieves got your gun by blowing the hinges off your steel gun safe that was bolted to the foundation of your house, then you should get a pass. However, if your gun was taken out of a glove compartment or a glass display case, well, you're screwed. If that seems unfair, perhaps you can complain to the loved ones of the victim that was killed with your gun.

This simple solution speaks directly to the fundamental problem of guns in America: it is the victims, not the gun owners, that bear the full responsibility for gun violence -- this despite the fact that victims don't have a say regarding the choices gun owners make with their guns that result in innocent people becoming victims. Victims don't ask gun owners to sell their guns to killers and they certainly don't ask to die. Though some believe the rights conferred by the Constitution regarding gun ownership are boundless, this is false. The notion that the deaths of innocent Americans are simply an unfortunate byproduct of the unlimited privilege afforded to gun owners to be reckless and irresponsible with their guns is as far outside the Constitution as it is obscene.

In the time it took me to write this article, seven more Americans were shot to death.

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Check out this incredible drone shot of a road slicing through...  

Check out this incredible drone shot of a road slicing through the forest near Pysht, Washington, USA. This one was captured and shared with us by @monascherie (at Pysht, Washington)

 
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Juxtapose by Tyler Rayburn  

Juxtapose by Tyler Rayburn

August 2015 This photo made me realize my fascination with architecture. I had never really been that interested in photographing in the city before, but during my 365 project I was constantly trying to do things that I've never done before so I decided to start taking a few pictures in the city and see how it might effect my work. Ever since this day I have loved photographing people & architecture! I'm sooooo glad that I went out and tried something new because it developed a completely new style and interest that I didn't know existed before. Now I love my work more than ever before! You will never know until you TRY. Just try. www.tylerrayburn.com/shop 15% off prints until the end of June then prices go up! (3 more days!)

Tyler Rayburn: Photos

 
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Blue Hour by Austin Scherbarth  

Blue Hour by Austin Scherbarth

Austin Scherbarth: Photos

 
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OUCH!  
A motorcyclist is lucky to be alive after crashing into an unsecured load that fell into the road.
The unidentified item dropped off a boat being towe...

Read more: Gif, Motorcycle Accident, Motorbike Accident, I 94, Linda Leverty, Weird News News

 
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Giving Ugly Fruits And Vegetables A Chance Will Make Us Better Citizens  
Ugliness has always been linked to nastiness and perversion. We've all seen the typecasts of the handsome good guy and the unattractive bad guy in Hollywood movies over the years. (Somehow, this formula is not as straightforward when it comes to the representation of female characters -- evil or malicious women can also have seductive attributes.)

Ugly fruits and vegetables are morally discriminated against. That is, they are treated with prejudice because of their unattractive appearance. As a result, 1.3 billion tons of food are tossed in the trash around the world every year.

These ugly fruits and vegetables can't compare with the dominant canon of fruits and vegetables. The latter look beautiful, and with their appearance comes an expectation for succulent tastes. As a result, millions of food items are pushed aside and thrown in dumps because they do not meet the aesthetic criteria of shape and color. Such aesthetic requirements are dictated by consumers and by retailer prerequisites. It is therefore more profitable to have identical merchandise that is easier to pack and store. For this reason, large-scale harvesters automatically get rid of vegetables and fruits that fall from grace.

There's an assumption that beauty and quality are connected by an unbreakable bond.

In my view, the criteria for what is ugly or beautiful is controversial. Some vegetables deviate from the required criteria -- these may include: An attractive carrot with two heads, a tomato with a horn, a twisted pepper, a gigantic and crooked cucumber or zucchini, sunburned Swiss chard or some spinach with tips weakened and rendered pale by the harsh sunlight.



But what is or is not acceptable is a cultural matter, and therefore can be changed. The differences we see in shape and color within one plant group (among apples, for example) makes us believe that ugly and beautiful fruits and vegetables will taste differently; the ugly ones will not be as tasty and may even be harmful for your stomach and health. There's an assumption that beauty and quality are connected by an unbreakable bond. Ugly fruits and vegetables are surrounded by negative stereotypes that breed fear and suspicion.

More and more people are becoming aware of this absurd discrimination against ugly vegetables, and the associated waste of tons of produce. For example, a well-known European supermarket chain has taken on the challenge of giving authentic rights to unattractive fruits and vegetables by offering them at more attractive prices. They are giving vegetables the right to be consumed, independently of their color or shape, and to be enjoyed without prejudice or discrimination. This initiative is undoubtedly inspired by the efforts of the European Union (2014 was the European year against food waste).

In my opinion, awareness, the feeling of self-efficiency, and responsibility are necessary ingredients for action and therefore for citizens' political participation.

There is a similar project run by the Portuguese company Fruta Horrible (Horrible Fruit), which uses ugly foods to help families who cannot pay full prices at the supermarkets.

It's obvious that the initiative by the supermarket chain mentioned above is based on commercial interests; interests that, without a doubt, we consider as legitimate. We look at this project from a pragmatic point of view: If it expands, if many other chains join this commercial adventure, many people around the world would have the opportunity to eat fruits and vegetables on a daily basis, and not only every once in a while.

Movements emerging in major cities, such as the ugly food movement, are very inspiring. This countercultural gesture subverts the relationship between the attractiveness of the food and its ability to nourish. If this movement grows, it would have obvious consequences for food, but it would also have a significant impact on the beliefs and attitudes of many human beings.

In my opinion, awareness, the feeling of self-efficiency, and responsibility are necessary ingredients for action and therefore for citizens' political participation.

Maybe our country would like to participate and launch campaigns so that consumers, distributors and sellers modify their beliefs and give ugliness a chance.

This post first appeared on HuffPost Spain. It has been translated into English and edited for clarity.

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CBP Agriculture Specialists at Anzalduas International Bridge Seize an Elephant Skull  

CBP Photography posted a photo:

ANZALDUAS, Texas Agriculture specialists with U.S. Customs and Border Protection, Office of Field Operations (OFO) at the Hidalgo/Pharr/Anzalduas Port of Entry have intercepted and seized an elephant skull that lacked proper ownership and exportation documentation, as required under U.S. and international law. Our CBP officers and agriculture specialists partner with the U.S. Fish and Wildlife Service (FWS) to enforce federal wildlife laws that protect vulnerable and endangered species.
Photo provided by U.S. Customs and Border Protection

 
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Domenico Fontana Scientist of the Day Domenica Fontana,...  

Domenico Fontana Scientist of the Day

Domenica Fontana, an Italian engineer, died June 28, 1607, at about age 64.  

read more…

 
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The <i>best</i> way to find oxygen on Mars? Friggin LASERS, of course  

Curiosity's beams reveal signs of manganese oxide

A chemical camera sitting atop Curiosity, the Mars rover, has spotted signs that the Red Planet may have once had oxygen in its atmosphere, fuelling further speculation that it was once Earth-like.…

 
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The recalled Jeep shifter is just bad user interface design  

The recalled Jeep shifter that may have been involved in Star Trek actor Anton Yelchin's death is a straightforward example of how things get harder to use when you take controls out of hardware and put them into software. It's a UI problem, and an entirely avoidable one.

First things first: if you have a 2014 or 2015 Jeep Grand Cherokee or a 2012-2014 Dodge Charger or Chrysler 300, you should call your dealer right now and set up an appointment for the recall. According to my local dealer, the update takes 3.5 hours, and it patches the car's software to engage the emergency brake if the driver's door is opened when the car is in neutral. That's it. It's a software update that was finally accelerated in the past few weeks after a death,...

Continue reading…

 
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Taktouka by Redouan Regrag  

Taktouka by Redouan Regrag

Music Heritage northern Morocco

Redouan Regrag: Photos

 
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pipe wall by Gilbert Claes  

pipe wall by Gilbert Claes

Gilbert Claes: Photos

 
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creations by Marta Bevacqua  

creations by Marta Bevacqua

follow me on facebook : https://www.facebook.com/MartaBevacquaPhotography/ or instagram @martabevacqua for more photos and news. www.martabevacquaphotography.com

Marta Bevacqua: Photos

 
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http://twitter.com/WFSA13/status/747771044212125696 
CITES, we as members of the South African public demand protection of this endangered species. PC, South Africa https://t.co/DWW5nSxsaA 
https://t.co/DWW5nSxsaA 

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Click For Fewer Calories: Health Labels May Change Online Ordering Habits  

Will it be a hamburger or hummus wrap for lunch? When customers saw indications of a meal's calorie content posted online, they put fewer calories in their cart, a study finds.

 
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My plan to heal this BROKEN, BREXITED BRITAIN  

The people have spoken. So we'll ask them again

¡Bong! [The following memo was found in a pilates studio in Shoreditch earlier this month, and forwarded to us anonymously. It is sourced to "BV Strategic Relations”, a highly secretive firm apparently registered in Panama, which describes itself as a "bespoke crisis management consultancy to governments”. The authenticity of the memo has been confirmed by to us by a representative of the firm, มาลัย (which means Garland of Flowers in Thai) - ed]…

 
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Beige  

AlbertoRossini posted a photo:

 
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Red Panda  

Mathias Appel posted a photo:

Reupload. Edited it a little differently.

 
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Ancient Shipwreck Off Greek Island Yields A Different Sort Of Treasure  

Divers exploring the famous Antikythera shipwreck, 200 feet beneath the water's surface in Greece, have turned up a heavy object they think might have been a powerful weapon in the first century B.C.

 
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Sharing your work cubicle with robots may not be such a bad thing  

New report by Forrester shows AI will create jobs in the future

Keep calm and carry on; artificial intelligence will not take all our jobs and achieve world domination, according to a report released by Forrester.…

 
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Blanco Telescope silhouetted against night sky  

Full Text:

Pictured here, the Cerro Tololo Inter-American Observatory's (CTIO) 4-meter Blanco Telescope is a silhouette against the Magellanic Clouds (at left) and the Milky Way, as seen from Cerro Tololo, Chile. CTIO provides qualified scientists with telescopes and related facilities for astronomical research in the Southern Hemisphere. CTIO has offices, labs and living quarters in the coastal city of La Serena, 482-kilometers north of Santiago. The observing facilities are on Cerro Tololo, a 2,194-meter mountain on the western slopes of the Andes Mountains, 64-kilometers inland from La Serena.

Image credit: Roger Smith/NOAO/AURA/NSF

 
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3-D printing produces cartilage from strands of bioink  

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Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is also a tissue that cannot repair itself. Once cartilage is damaged, it remains damaged.

Image credit: Ibrahim Ozbolat, Penn State University

 
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