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Tower Bridge  

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Anticancer drug discovery: A family of enzymes  

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When doctors hurl toxic death at cancer cells, often a few will survive and come back. A family of enzymes called KDM5 histone demethylases is emerging as important for this resilience and drugs that inhibit KDM5 enzymes could be active in treating several types of cancer. A team of investigators obtained detailed structural information, showing how inhibitors of the KDM5 family interact with their targets by building a molecular model of the KDM5A enzyme, along with an inhibitor bound in the active site. Their findings could inform efforts to design more potent and selective anticancer drugs.

Image credit: From Horton et al, Cell Chem Bio (2016)

 
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Blue jet lightning  

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This is the first image ever captured of blue jet lightning. It was taken at Arecibo Observatory in Chile. A team of researchers at Arecibo captured video evidence from the ground of this lightning phenomenon known as blue jet. The discovery is the first ground-based evidence linking the ionosphere with cloud tops in blue jet events. According to Victor Pasko of Penn State University, an electrical engineer working at Arecibo, pilots and others reported observations of red sprites and blue jets long before the first one was captured on video, and numerous undocumented reports of similar phenomena have appeared in scientific literature for over a century.

Image credit: Victor Pasko, Penn State University

 
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New Mars rover is GO for 2020 says NASA  

This time we'll hear the sounds of Mars, if the enhanced Sky Crane works

All being well, NASA will launch the successor to Curiosity Rover in 2020. And this time the agency hopes to prepare samples for an as-yet-blue-sky manned mission that could one day return them to Earth for analysis.…

 
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Happy 50th birthday, optical fibres for telecoms  

In July 1966, Charles Kao looked into glass and saw the future of telecoms

One of the seminal developments in modern telecommunications turns 50 years old this month: the paper that bootstrapped the world of optical fibre communications.…

 
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http://twitter.com/gangactor/status/754845295893094400 
#wildlife trade #Tigers #CITES #Thailand #Trafficking #TigerTemple #Biodiversity #conservation #endangered #species https://t.co/BxQaIrR2Em 
https://t.co/BxQaIrR2Em 

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Clockwork Orange  

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Africa's MeerKAT looks at the sky, surprises boffins with 1,300 galaxies  

SKA precursor publishes 'first light' images

The operators of the MeerKAT radio telescope in South Africa have switched on its first 16 dishes and, pretty much immediately, spotted more than 1,200 new galaxies.…

 
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40-year-old chorus frog tissues vital to Louisiana hybrid zone study  
Researchers are shedding light on how often and where species hybridize through time, thanks to the rediscovery of 40-year-old tissue samples preserved at the LSU Museum of Natural Science. In a recent study, they show that two species of chorus frogs now form hybrids across a much wider area of Louisiana and Mississippi than they did just 30-40 years earlier. A widening area of hybridization has important implications for the future of these species and suggests that recent alterations to their environment have affected their fitness or dispersal ability.  
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Ptarmigan in Colorado have varied reproduction, not likely linked to warming trends  
Ptarmigan, which live in cold ecosystems, are not strongly affected by fluctuations in seasonal weather at two populations studied in Colorado, report scientists.  
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World's greatest concentration of unique mammal species is on Philippine island  
Luzon, the largest island in the Philippines, is home to the world's greatest concentration of unique mammal species -- 93 percent of the land mammals there are found nowhere else. A new paper announces that 52 of the island's 56 non-flying mammals live nowhere else in the world. Of these 56 species, 28 were discovered during the course of the 15-year project. The study provides insight into how island evolution works, and could inform future conservation efforts.  
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Photos of the Day: July 17, 2016  

Explore the news of the day with these images from around the world.  
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All There Is  

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I took another walk to my new favourite local spot.

 
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pornhashtag.com  

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VISIT: goo.gl/RX2WI1

 
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Did Oil Kill The Dinosaurs?  
Over the years, paleontologists were slightly dissatisfied by the idea that a large celestial body led to the extinct ion of the dinosaurs. Now, a paper suggests that an asteroid striking an underground reservoir of oil could have been the catalyst to end the Cretaceous.  
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How A Slobbering 80-Pound Pit Bull Changed My Life Forever  


Last year, my oldest son Matthew had gone off to college, and I was commuting between DC and LA. Things at home we not as "busy" as they used to be. We still had our 15-year-old Gabriel with us, but we missed the banter between brothers that used to fill the house. It just wasn't the same anymore.

Martha had a crazy idea: "Let's go the shelter and get a dog," she told me. I was not exactly thrilled with the idea but agreed. I mean what better way to replace a kid that has gone off to college then to get a dog, right? It had to be the "right dog"; I didn't want some yappy ankle biter or some vicious pit bull. I have had many an encounter with pit bull's in dark back yards during my time on the streets.

We went to the Carson, California Animal Shelter. It's a high kill facility due to the sheer number of dogs that are brought into the shelter. We wanted to find a dog and save a life at the same time. We walked in, and it seemed like every dog was a pit bull. I was dead set against taking one home, because I knew they were a vicious breed, and I was not going to let one of those animals into my home.

While I walked along the rows and rows of cold metal cages, a dog caught my eye. He was scared, emaciated and looked like he had given up on life.

There was only one problem: He was a pit bull.

He looked at me with big beautiful eyes. I could see into his soul. I could feel how scared he was and that he just wanted it to end. I could not just walk away -- my heart would not let me. I had to at least go over and look at him.

I felt everything that this poor creature was feeling right then. He just wanted to be loved; he just wanted a home and a family.

I approached his cage. He did not move. He did not bark. He just sat there with his big head resting against the metal cage. I stuck my finger though the hole in the cage and scratched him on the head. I expected him to growl or flinch, but he did not. He closed his eyes and accepted all the love that my one finger could give him. I knew that this dog had never felt love before. I think he was enjoying every bit of the love I could give him, savoring it all until his time came to leave the earth.

Tears began to stream down my face (I am crying right now as I write this) because I felt everything that this poor creature was feeling right then. He just wanted to be loved; he just wanted a home and a family.

I called my wife Martha and son Gabriel over and told them, "I want to see if this is the dog for us." We arranged for a little private time with the dog. He was shaking as the shelter workers brought him out of his cage. Maybe he was thinking that his time had come. We spent time with him. He was so scared that he didn't move. He didn't bark or growl. It was his eyes that told us what we needed to do, so we took a chance on this pit bull and said, "We want him."

He had to stay at the shelter a few more days to get neutered, so they took him back to his cold metal cage. I felt so bad that he was not able to let him know that he now had a family. We visited him every day in the shelter until we could take him home. We wanted him to know love, to know affection and that he was important.

I know what's in those eyes: It's love, compassion and gratitude. Things I never thought that a pit bull was capable of.

It's been a year since we took Carson home (we named him after the shelter) and our lives have been changed forever. He has gained lots of weight from snacks and treats and his ribs no longer show. He has a new "little brother" in Carter, the scrappy white terrier we adopted from the shelter to be his friend.

Carson's favorite thing to do is to leap up in the air onto our bed in the morning and give us kisses with his giant pit bull tongue. He is always there to greet us when we come home with a huge smile and wagging tail. We never eat alone, because Carson is always nearby, drooling all over the floor hoping for some "nummy nummies."

Our lives are so much better because of this giant, 80-lb. pit bull. He has shown us more love than any living creature on earth ever has before. I love looking into his big brown eyes as his giant tongue slides across my face. I know what's in those eyes: It's love, compassion and gratitude. Things I never thought that a pit bull was capable of.

Taking a chance on an 80-lb. pit bull was the best decision my family ever made. If you are looking for a great dog, maybe you can find a "Carson" of your own.



Also on HuffPost:

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7-Eleven Clerk Beats Robber At Terrifying Game Of Tug-Of-War  
A brave 7-Eleven clerk in Frederick, Maryland, held his own when a masked armed robber burst into the store.
He grabbed the shotgun that the raider wa...

Read more: Viral Video, Gif, 7 Eleven, Tug of War, Frederick, Crime News

 
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Big Ben sunset #2  

olga_vasiljeva posted a photo:

London

 
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The Capital  

aevo69 posted a photo:

View from the 72 floor of the Shard, looking towards St Pauls Cathedral. What a place.

 
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Westminster Bridge  

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Houses of Parliament with the famous clock

 
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Check out this incredible shot of tankers tied up at the Port of...  

Check out this incredible shot of tankers tied up at the Port of Rotterdam in Holland. From 1962 until 2002, Rotterdam was the world's busiest port, but was overtaken first by Singapore and later by Shanghai. This photo was captured via drone and shared with us by our friend @digitalanthill (at Port Of Rotterdam)

 
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DSC_0286 Sunset in Knightsbridge Kensington London  

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Sunset in Knightsbridge Kensington London

 
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DSC_0287 Sunset in Knightsbridge Kensington London  

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Sunset in Knightsbridge Kensington London

 
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DSC_0288 Winter Sunset in Kensington London  

photographer695 posted a photo:

Sunset in Kensington London - This was the true colour of the sky. No photoshop enhancement.

 
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DSC_0289 Sunset in Kensington London  

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Sunset in Knightsbridge Kensington London

 
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