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City of London as seen from Greenwich Park
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When doctors hurl toxic death at cancer cells, often a few will survive and come back. A family of enzymes called KDM5 histone demethylases is emerging as important for this resilience and drugs that inhibit KDM5 enzymes could be active in treating several types of cancer. A team of investigators obtained detailed structural information, showing how inhibitors of the KDM5 family interact with their targets by building a molecular model of the KDM5A enzyme, along with an inhibitor bound in the active site. Their findings could inform efforts to design more potent and selective anticancer drugs.
Image credit: From Horton et al, Cell Chem Bio (2016)
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This is the first image ever captured of blue jet lightning. It was taken at Arecibo Observatory in Chile. A team of researchers at Arecibo captured video evidence from the ground of this lightning phenomenon known as blue jet. The discovery is the first ground-based evidence linking the ionosphere with cloud tops in blue jet events. According to Victor Pasko of Penn State University, an electrical engineer working at Arecibo, pilots and others reported observations of red sprites and blue jets long before the first one was captured on video, and numerous undocumented reports of similar phenomena have appeared in scientific literature for over a century.
Image credit: Victor Pasko, Penn State University