The Guardian's picture editors bring you a selection of photo highlights from around the world, including opera and lord mayors in Yorkshire
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From Matthew McConaughey to Rachel McAdams, John Travolta to Jessica Lange, Terrence Howard to Taraji P. Henson, acclaimed actors who travel to television from the big screen tend to bring a lot of attendant hoopla with them—provided their shows air in prime-time, apparently. That's the only reason I can think of that Tony- and Oscar-nominee John C. Reilly isn't regularly showered in praise for what he's been doing on late-night ratings powerhouse Adult Swim on a weekly basis this summer. The star of films ranging from Talladega Nights to We Need to Talk About Kevin, Reilly is anchoring the fourth season of Check It Out! With Dr. Steve Brule, the bizarre local-news parody from co-creators Tim Heidecker and Eric Wareheim. (The season finale airs tonight at 12:15 a.m.) Reprising a role he developed over five seasons of the pair's Tim and Eric Awesome Show, Great Job!, he plays Dr. Steve, the semi-functional host of a disastrous human-interest show. And word to the wise, he's delivering one of the best comedic performances on TV.
It starts with the character's look. Reilly's physical appearance has always served him well as an actor. There's something about the combination of his large frame and round, expressive face that makes him look not so much tall as overgrown, like a child stretched to adult proportions. This gives him an air of vulnerability that belies his size; it lends pathos to his dramatic performances, like the sad-sack cop in Magnolia, and a goofball naïveté to his comedic turns, like the fake music legend in Walk Hard: The Dewey Cox Story. It's how a guy who's six-foot-two can sing the ode to interpersonal invisibility “Mr. Cellophane” in the film adaptation of Chicago and earn an Oscar nomination, or pair up with the relatively diminutive Mark Wahlberg in Boogie Nights and come across like a natural sidekick.
In these strictly physical terms alone, Dr. Steve is his magnum opus, the idiot man-child he was born to play. Wearing a brown suit that's at least two sizes too small, teasing his curly hair to fright-wig proportions, twisting his mouth and squinting his eyes to give his face a vibe of permanent confusion, Reilly leans into his quirks as Dr. Steve.
It's the sort of role that demands slapstick with an almost Newtonian certainty, and Reilly never fails to rise, or more accurately fall, to the occasion. Dr. Steve stomps, lurches, and bumbles through every segment; even something as simple as standing still and introducing his latest topic can end in physical havoc, with smashed props and toppled glass-brick sets. This being a Tim and Eric production, the pratfalls often stretch into cringe-comedy territory. In last week's episode alone, Brule tripped on the way to the soundstage and cut his head so badly that his producer stapled the wound shut on camera; he got hit hard enough in the head with a baseball bat during a piñata stunt gone wrong that he vomited from the impact. For a performer equally at home in absurd Judd Apatow comedies and painful Paul Thomas Anderson dramas, the blend of funny-ha-ha and funny-yikes is ideal.
But it's the sense that you're watching a toddler in the body of a large middle-aged man that gives Reilly/Brule his best material. Dr. Steve greets his topics—space, friends, cars, music, eggs—with appropriately childlike wonder and delight, his twinkling eyes and introductory shout of “Let's check it out!” evoking Christmas-morning levels of enthusiasm. He reacts to his guests with a complete lack of guile, whether holding their hands and kissing them on the head or announcing their physical flaws to the world like a child ignoring his mother's advice that it's impolite to point. He'll eat anything put within range of his mouth, from seafood out of a dumpster to MDMA offered by a strip-club owner. The result is often gross-out body-fluid humor that Reilly throws himself into with terrifying commitment; the scene in which he “had to go to the bathroom at both ends” after having too much to drink at a leather bar he mistook for a Hell's Angels hangout is the ne plus ultra of the genre. When he gets hurt, insulted, excluded, or frightened, he cries, sulks, panics, and screams so convincingly you want to go get his parents. (Unfortunately, his mother, Dorris Pringle-Brule-Salahari, is an abusive murderer who kept him caged in the basement as a boy after his fry-cook father skipped town, so that rules that out.)
Then there's his voice, a masterful mangling of pronunciation and grammar that's the character's trademark. Back when Brule was a recurring character on Awesome Show, Reilly played him relatively straight, sounding simply dopey rather than deranged. Once he became the star of his own series, however, his speech pattern took a turn for the weird. He adds unnecessary “r”s to the opening consonants of words: “boats” becomes “broats,” “pirate” becomes “prirate,” “puppets” becomes “pruppets,” and so on. (The bit during an episode on fear where he popped out from behind the set and shouted “Broo!” may be the series' funniest moment.) He's incapable of properly pronouncing anyone's name, and he's often not even in the ballpark; those that begin with “D” are especially taxing on him for some reason, and Davids, Dans, and Dons are invariably mangled into something like Dang or Dong or Drungus. The preposition “of” gets a real workout, most memorably when the Doctor discovers that when it comes to American currency, “one of paper equals four of coin.” And there's a mushmouthed quality to his voice throughout, as if he'd been suddenly awoken from a nap just before the camera started rolling. (The overall effect is so strange and singular that it defuses criticism that the character is some sort of mean-spirited ableist stereotype: No real person on Earth sounds like this.)
And as ill at ease as Brule appears in his man-on-the-street segments, he fits right in to the peculiar public-access world Heidecker and Wareheim have built around him. The VHS-distortion effects, the no-budget graphics and set design, the cast of non-actors playing Brule's fellow Channel 5 employees, the occasional eruptions of Mulholland Drivelevel menace amid the ridiculousness: Dr. Steve's solo show is the Tim & Eric aesthetic in its purest form, at a time when the pair's other ventures (notably their bigger-budget recent series Bedtime Stories) have largely moved away from the deliberately crude, visually noisy look that once defined them. As Reilly's collaborators, they seem determined to rise to his level of calculated madness. I don't think it's an exaggeration to compare this relationship to Sam Esmail and Rami Malek on Mr. Robot or Bryan Fuller and Mads Mikkelsen on Hannibal, in the sense that the look and work of the performer enables the filmmaker to take things farther than they otherwise could. That's the mark of a great performance, no matter how odd it looks, or how late you have to stay up to see it.
See also: Watch John C. Reilly and Crispin Glover in Drunk History: Nikola Tesla
Commentators often criticize Hillary Clinton for having a loud, monotone, and shrill voice. In this video, The Atlantic's Olga Khazan talks to voice experts to understand what makes Hillary's voice allegedly more annoying than her competitors. The conclusions are complex: Clinton's voice is actually average in pitch and loudness for her age and gender, but she does yell into microphones and speak in an overly annunciated voice—two factors that may make her seem abrasive. And then, of course, there's another element at play: sexism.
Imagine a pill you can take to speed up your thought processes, boost your memory, and make you more productive. If it sounds like the ultimate life hack, you're not alone. There are pills that promise that out there, but whether they work is complicated. Here are the most popular cognitive enhancers available, and what science actually says about them.
When you hear about nootropics, often called “smart drugs,” you probably picture something like the scene above from Limitless, where Bradley Cooper's character becomes brilliant after downing a strange pill. The drugs and supplements currently available don't pack that strong of a punch, but the concept is basically the same. Many nootropics have promising benefits, like boosting memory, focus, or motivation, and there's research to support specific uses. But the most effective nootropics, like Modafinil, aren't intended for use without a prescription to treat a specific condition. In fact, recreational use of nootropics is hotly-debated among doctors and medical researchers. Many have concerns about the possible adverse effects of long-term use, as well as the ethics of using cognitive enhancers to gain an advantage in school, sports, or even everyday work.
None of that has kept entrepreneurs and their customers from experimenting and buying into the business of magic pills, however. In 2015 alone, the nootropics business raked in over $1 billion dollars, and web sites like the nootropics subreddit, the Bluelight forums, and Bulletproof Exec are popular and packed with people looking for easy ways to boost their mental performance. Still, this bizarre, Philip K. Dick-esque world of smart drugs is a tough pill to swallow. To dive into the topic and explain, I spoke to Kamal Patel, Director of evidence-based medical database Examine.com, and even tried a few commercially-available nootropics myself.
http://gizmodo.com/nootropics-and…
Without a doubt, the two most popular nootropics are compounds you've likely ingested on many occasions: caffeine and L-theanine. Both are found in coffee and green tea, but in small amounts when compared to the nootropic doses available.
We've talk about how caffeine affects the body in great detail, but the basic idea is that it can improve your motivation and focus by increasing catecholamine signaling. Its effects can be dampened over time, however, as you start to build a caffeine tolerance. Research on L-theanine, a common amino acid, suggests it promotes neuronal health and can decrease the incidence of cold and flu symptoms by strengthening the immune system. And one study, published in the journal Biological Psychology, found that L-theanine reduces psychological and physiological stress responses—which is why it's often taken with caffeine. In fact, in a 2014 systematic review of 11 different studies, published in the journal Nutrition Review, researchers found that use of caffeine in combination with L-theanine promoted alertness, task switching, and attention. The reviewers note the effects are most pronounced during the first two hours post-dose, and they also point out that caffeine is the major player here, since larger caffeine doses were found to have more of an effect than larger doses of L-theanine.
http://lifehacker.com/5585217/what-c…
While these two compounds may not be as exciting as a super pill that instantly unlocks the full potential of your brain, they currently have the most science to back them up. And, as Patel explains, they're both relatively safe for healthy individuals of most ages. Patel explains that a combination of caffeine and L-theanine is the most basic supplement stack (or combined dose) because the L-theanine can help blunt the anxiety and “shakiness” that can come with ingesting too much caffeine.
A 100mg dose of caffeine (half of a No-Doz or one cup of strong coffee) with 200mg of L-theanine is what the nootropics subreddit recommends in their beginner's FAQ, and many nootropic sellers, like Peak Nootropics, suggest the same. In my own experiments, I used a pre-packaged combination from Nootrobox called Go Cubes. They're essentially chewable coffee cubes (not as gross as it sounds) filled with that same beginner dose of caffeine, L-theanine, as well as a few B vitamins thrown into the mix. After eating an entire box of them (12 separate servings—not all at once), I can say eating them made me feel more alert and energetic, but less jittery than my usual three cups of coffee every day. I noticed enough of a difference in the past two weeks that I'll be looking into getting some L-theanine supplements to take with my daily coffee.
Racetams, specifically Piracetam an ingredient popular in over-the-counter nootropics, are synthetic stimulants designed to improve brain function. Patel notes Piracetam is the granddaddy of all racetams, and the term “nootropic” was originally coined to describe its effects. However, despite its popularity and how long it's been around and in use, researchers don't know what its mechanism of action is. Patel explained that the the most prominent hypothesis suggests Piracetam enhances neuronal function by increasing membrane fluidity in the brain, but that hasn't been confirmed yet. And Patel elaborated that most studies on Piracetam aren't done with the target market for nootropics in mind, the young professional:
The majority of studies seem to be done on types of people who are NOT buying nootropics. Like the elderly, people with blatant cognitive deficits, etc. This is analogous to some of the muscle-building research but more extreme. Like there are studies on some compound increasing muscle growth in elderly patients or patients with wasting, and supplement companies use some of those studies to back their supplements.
That said, there are plenty of studies out there that point to its benefits. One study, published in the British Journal of Pharmacology, suggests brain function in elderly patients can be greatly improved after regular dosing with Piracetam. Another study, published in the journal Psychopharmacology, found that Piracetam improved memory in most adult volunteers. And another, published in the Journal of Clinical Psychopharmacology, suggests it can help students, especially dyslexic students, improve their nonverbal learning skills, like reading ability and reading comprehension. Basically, researchers know it has an effect, but they don't know what or how, and pinning it down requires additional research.
So I decided to try some.
Over the course of a few weeks, I took doses of Piracetam (around 1600mg three times a day), and I noticed a slight change in my focus. It was easier for me to sit down and power through my writing, I didn't get distracted while doing research, and it noticeably improved my Crucible scores in Destiny.
However, when I didn't stack it with Choline, I would get what users call “racetam headaches.” Choline, as Patel explains, is not a true nootropic, but it's still a pro-cognitive compound that many take with other nootropics in a stack. It's an essential nutrient that humans need for functions like memory and muscle control, but we can't produce it, and many Americans don't get enough of it. The headaches I got weren't terribly painful, but they were uncomfortable enough that I stopped taking Piracetam on its own. Even without the headache, though, I didn't really like the level of focus Piracetam gave me. I didn't feel present when I used it, even when I tried to mix in caffeine and L-theanine. And while it seemed like I could focus and do my work faster, I was making more small mistakes in my writing, like skipping words. Essentially, it felt like my brain was moving faster than I could.
Of all the smart drugs in the world, Modafinil is most often touted as the best. It's a powerful cognitive enhancer, great for boosting alertness, and has very few, mild side effects that most healthy users will never experience. And no, you can't have any. Sorry. Modafinil is a prescription medication used to treat disorders like narcolepsy, shift work sleep disorder, and for those who suffer from obstructive sleep apnea.
As with other nootropics, the way it works is still partially a mystery, but most research points to it acting as a weak dopamine reuptake inhibitor. Put simply, it increases your dopamine levels the same way cocaine does, but in a much less extreme fashion. The enhanced reward system it creates in the brain, however, makes it what Patel considers to be the most potent cognitive enhancer available; and he notes that some people go from sloth to superman within an hour or two of taking it.
But perhaps the biggest difference between Modafinil and other nootropics like Piracetam, according to Patel, is that Modafinil studies show more efficacy in young, healthy people, not just the elderly or those with cognitive deficits. That's why it's great for (and often prescribed to) military members who are on an intense tour, or for those who can't get enough sleep for physiological reasons. One study, by researchers at Imperial College London, and published in Annals of Surgery, even showed that Modafinil helped sleep-deprived surgeons become better at planning, redirecting their attention, and being less impulsive when making decisions.
So what's the catch? Well, it's potentially addictive for one. Anything that messes with your dopamine levels can be. And Patel says there are few long-term studies on it yet, so we don't know how it will affect your brain chemistry down the road, or after prolonged, regular use. Also, you can't get it very easily, or legally for that matter, if you live in the U.S. It's classified as a schedule IV controlled substance. That's where Adrafinil comes in.
Adrafinil is a prodrug for Modafinil, which means it can be metabolized into Modafinil to give you a similar effect. And you can buy it legally just about anywhere. But there are a few downsides. Patel explains that you have to take a lot more to achieve a similar effect as Modafinil, wait longer for it to kick in (45-60 minutes), there are more potential side effects, and there aren't any other benefits to taking it.
I've had some success with nootropics, but your mileage may vary. And because I'm not a scientist or a doctor, it's hard for me to say for certain how much they helped. Did they work? Or did I really want them to work? As Patel explains, it's important to distinguish the placebo effect from a real effect, especially with nootropics:
With something like creatine, you'd know if it helps you pump out another rep at the gym on a sustainable basis. With nootropics, you can easily trick yourself into believing they help your mindset. The ideal is to do a trial on yourself. Take identical looking nootropic pills and placebo pills for a couple weeks each, then see what the difference is. With only a third party knowing the difference, of course.
Most research on these nootropics suggest they have some benefits, sure, but as Barbara Sahakian and Sharon Morein-Zamir explain in the journal Nature, nobody knows their long-term effects. And we don't know how extended use might change your brain chemistry in the long run. Researchers are getting closer to what makes these substances do what they do, but very little is certain right now. If you're looking to live out your own Limitless fantasy, do your research first, and proceed with caution.
Animation by Angelica Alzona. Photos by paul_hoole and Anders Sandberg.
Mongabay: Redonda's invasive black rats and long-horned goats have transformed the once-forested island into a ‘moonscape', conservationists say
The remote Caribbean island of Redonda, part of Antigua and Barbuda, is home to numerous species of plants and animals found nowhere else on earth. It is also home to invasive black rats and non-native goats that are wiping out the island's native, rare wildlife, conservationists say.
To help the island's flora and fauna, the Government of Antigua and Barbuda is now initiating a plan to remove all goats and rats from the island. The Redonda Restoration Program program has been formed by the Antigua & Barbuda Government and the Environmental Awareness Group (EAG) in collaboration with organizations like Fauna & Flora International, British Mountaineering Council, Island Conservation and Wildlife Management International Ltd.
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Google and drug giant GlaxoSmithKline are spending £540m on a new joint venture, Galvani Bioelectronics, in a bid to develop and commercialise bioelectronic medicine.…
felixhelgesson posted a photo:
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A group of Irish trainee priests are being packed off to Roma, after claims some fathers-in-training at their existing berth in the Emerald Isle had developed a predilection for gay hookup site Grindr.…
Green is the New Black (Green Chickpeas With Black Rice and Green Tahini Dressing)
Whether it's red beans and rice or rice and chickpeas, beans and rice is the most important dish in the world. Here nutty-flavored, nutrient-dense black rice changes it up from basic brown, so do sweet green chickpeas instead of the standard blonde ones The parsley-infused tahini dressing has a bold flavor and adds a designery pale green accent to a dish that may be served hot or -- to beat the summer heat -- at room temperature.
For black rice:
1 cup black rice
2-1/2 cups water or vegetable broth
sea salt to taste
juice of 1 lemon (about 2 tablespoons)
In a large pot set on high heat, bring water or broth to boil. Pour in the rice. Cover, reduce heat to low and simmer for 30 minutes. Grains will swell and become tender but retaining some chew. Drain off any remaining cooking liquid. Add sea salt to taste and lemon juice, Set aside.
For the green chickpeas:
2 cups green chickpeas, thawed (you can also use the standard blonde ones)
1 handful each mint, cilantro and flat-leaf parsley, finely chopped
2-3 tablespoons green tahini dressing (recipe below)
sea salt to taste
Pour 1-1/2 cups of the chickpeas into a large bowl, reserving the remaining 1/2 cup for garnish. Add the chopped herbs to the bowl, mix together and add 2 to 3 tablespoons of the green tahini dressing. Season with sea salt.
For the green tahini dressing:
1/4 c lemon juice
1 clove garlic
1/2 cup tahini
1/2 cup water
1 cup flat-leaf Italian parsley, tightly packed (about 1/2 bunch)
1/4 teaspoon sea salt
pinch turmeric (if desired)
Whizz everything together in a blender or food processor until thick, creamy and smooth. Cover and refrigerate. Dressing will thicken as it chills. Thin with another 3-4 tablespoons of water, if desired.
Makes 1-1/2 cups, or 8 to 10 servings. Dressing keeps covered and chilled for a week.
To assemble:
Mound dressed chickpeas atop black rice, garnishing with the 1/2 cup of plain chickpeas for an extra pop. Pour remaining green tahini dressing in a bowl to drizzle on top, if desired.
Serves 4 to 6.
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Jean-Baptiste Lamarck Scientist of the Day
Jean-Baptiste Lamarck, a French botanist and invertebrate zoologist, was born Aug. 1, 1744.
Cognitive Dissonance Inside Higher Ed (blog) Last week I joined 39 other community college people at an Aspen Institute workshop at Stanford. I'm still recovering from the cognitive dissonance. The workshop was terrific -- I'm still chewing on a lot of the material, and some of it will find its ... |